A Classification Model for Class A GPCR ECL2 domains

Abstract

The extracellular loop 2 (ECL2) is the longest and the most diverse loop among class A G protein-coupled receptors (GPCRs). We propose a 7-cluster classification scheme of currently resolved ECL2 domains based on volume overlaps and their intermolecular interactions with the other GPCR regions.

Reference

See: A. Nicoli, A. Dunkel, T. Giorgino, C. de Graaf, and A. Di Pizio. A Classification Model for the Second Extracellular Loop of Class A GPCRs, Journal of Chemical Information and Modeling, 2022. doi:10.1021/acs.jcim.1c01056

Query the ECL2 clusters

Selected ECL2 cluster

Distinct clusters A to G have been assigned on the basis of volumetric overlaps. See the paper for details.

Data set

GPCRmd (molecular dynamics)

RCSB PDB (experimental)

Summary of selected GPCRs

Select links under the ID column to download the corresponding PDB structure. Hovering under ECL2 provides a preview.